Mitochondrial DNA Genome
Mitochondrial DNA
- One or more DNA (2-6) can present in mitochondrial Matrix
- Size- 6µ Long
- Animal – Small – 16-19kb
- Yeast and Plant – Large- 100-200kb
- Human – m-DNA – 16579 bp – Introns Absent –13 protein code
- Yeast – 78000 bp-Intron +nt
- Smallest mt – genome /DNA- Plasmodium falciparum – 6kb – code only 3 protein
- It is Circular, dsDNA, and Supercoiled
- Self Replicate
- High G+C content
- MW- 9-11X106
- Origin – G2 Phase
- It encode – rRNA and tRNA and 20 types of Proteins
- No to attach – Histone protein
- Its DNA pol is different to N-DNA Pol
Mitochondrial RNA
- These are different to cytoplasmic RNA
- In this – 23s 16s, 4s types of RNA are present
- These are resistant to Ribo-nuclease enzyme
- Mitochondria have 70s types of Ribosome
- In it Protein synthesis can be inhibited by Chloramphenicol
